载脂蛋白CII

定义

载脂蛋白CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. It is also found in very low density lipoprotein (VLDL), which is made up of mostly triglycerides (a type of fat in your blood).

This article discusses the test used to check for apoCII in a sample of your blood.

选择的名字

ApoCII; Apoprotein CII; ApoC2; Lipoprotein lipase deficiency - apolipoprotein CII; Chylomicronemia syndrome - apolipoprotein CII

如何执行测试

需要血液样本.

How to Prepare for the Test

You may be told not to eat or drink anything for 4 to 6 hours before the test.

考试的感觉如何

When the needle is inserted to draw blood, you may feel some pain, or only a prick or stinging. Afterward, there may be some throbbing where the needle was inserted.

Why the Test is Performed

ApoCII measurements can help determine the type or cause of high blood fats. It is not clear whether the test results improve treatment. Because of this, most health insurance companies will not pay for the test. If you do not have high cholesterol or heart disease or a family history of these conditions, this test may not be recommended for you.

正常的结果

The normal range is 3 to 5 mg/dL. However, apoCII results are usually reported as present or absent.

The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

What Abnormal Results Mean

High levels of apoCII may be due to a family history of lipoprotein lipase deficiency. This is a condition in which the body does not break down fats normally.

Low ApoCII levels are also seen in people with a rare condition called familial apoprotein CII deficiency. 这将导致 chylomicronemia综合症, another condition in which the body does not break down fats normally.

风险

风险 associated with having blood drawn are slight but may include:

• 大出血
• Fainting or feeling lightheaded
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

注意事项

Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown.

参考文献

Bredefeld CL, Lau R, Hussain MM. Lipids and dyslipoproteinemia. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. St Louis, MO: Elsevier; 2022:chap 18.

法齐奥S，林顿MF. Regulation and clearance of apolipoprotein B-containing lipoproteins. 见:balantyne CM编. Clinical Lipidology: A Companion to Braunwald's Heart Disease. 第二版. Philadelphia, PA: Elsevier; 2015:chap 2.

Genest J, Mora S, 利比P. Lipoprotein disorders and cardiovascular disease. In: 利比P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12日艾德. Philadelphia, PA: Elsevier; 2022:chap 27.

利比P. The Vascular biology of atherosclerosis. In: 利比P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12日艾德. Philadelphia, PA: Elsevier; 2022:chap 24.

Meeusen JW, Ueda M, Nordestgaard BG, Remaley AT. 脂质和脂蛋白. In: Rifai N, Chiu RWK, Young I, Burnham C-A D, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7日艾德. St Louis, MO: Elsevier; 2023:chap 36.

罗宾逊詹. Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil医学. 26日艾德. Philadelphia, PA: Elsevier; 2020:chap 195.