TBG血检

定义

The TBG血检 measures the level of a protein that moves thyroid hormone throughout your body. This protein is called thyroxine-binding globulin (TBG).

选择的名字

Serum thyroxine binding globulin; TBG level; Serum TBG level; Hypothyroidism - TBG; 甲状腺机能亢进 - TBG; Underactive thyroid - TBG; Overactive thyroid - TBG thyroid hormone binding globulin

如何执行测试

A 血液样本 is taken and then sent to a laboratory for testing.

How to Prepare for the Test

Certain drugs and medicines can affect test results. Your health care provider may tell you to stop taking a certain medicine for a short time before the test. Never stop taking any medicine without first talking to your provider.

These medicines and drugs can increase TBG level:

• Estrogens, found in birth control pills and estrogen replacement therapy
• 海洛因
• 美沙酮和阿片类药物
• Phenothiazines (certain antipsychotic drugs)

The following medicines can decrease TBG levels:

• Depakote or depakene (also called valproic acid)
• Dilantin (also called phenytoin) and carbamazepine
• High doses of salicylates, including aspirin
• Male hormones, including androgens and testosterone
• Prednisone or other glucocorticoids (steroids)

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. 这很快就会消失.

为什么要进行测试

This test may be done to diagnose problems with your thyroid.

正常的结果

Normal range is 13 to 39 micrograms per deciliter (mcg/dL), or 150 to 360 nanomoles per liter (nmol/L).

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different samples. Talk to your provider about the meaning of your specific test results.

异常结果意味着什么

An increased TBG level may be due to:

• 急性 intermittent porphyria (a rare metabolic disorder)
• Hypothyroidism (underactive thyroid)
• 肝脏疾病例如肝炎
• Pregnancy (TBG levels normally increased during pregnancy)

Note: TBG levels are normally high in newborns.

Decreased TBG levels may be due to:

• 急性 疾病
• 肢端肥大症 (disorder caused by too much growth hormone)
• 甲状腺机能亢进 (甲状腺功能亢进)
• 营养不良
• 肾病综合症 (symptoms that show kidney damage is present)
• 手术压力

High or low TBG levels affect the relationship between total T4 and free T4 blood tests. A change in TBG blood levels can alter the appropriate dose of levothyroxine replacement for persons with hypothyroidism.

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a 血液样本 from some people may be more difficult than from others.

Other risks of having blood drawn are slight, but may include:

• 大出血
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood buildup under the skin)
• Infection (a slight risk any time the skin is broken)

参考文献

Guber HA, Oprea M, Russell YX. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 25.

克鲁斯是. 甲状腺疾病. In: Parrillo JE, Dellinger RP, eds. Critical Care Medicine: Principles of Diagnosis and Management in the Adult. 5日艾德. Philadelphia, PA: Elsevier; 2019:chap 57.

Salvatore D, Cohen R, Kopp PA, Larsen PR. Thyroid pathophysiology and diagnostic evaluation. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 11.